Sr Scientist Engineering and Material Sciences at Vertex Pharmaceuticals in Boston, MA

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Job Description:

The successful candidate will be a highly productive, results-oriented individual, able to multi-task and generate and implement original ideas that contribute to the successful development and scale-up of drug manufacturing processes. Strong communication, organization, and planning skills and a high level of technical aptitude and creativity are required for success in this position

Key Responsibilities:
  • Support drug substance process definition and development via laboratory development, pilot plant scale-up, drug supply preparation, and technology transfer to third party manufacturing facilities.
  • Possess a sound scientific understanding of chemistry and chemical engineering fundamentals, the development of pharmaceutical unit operations, and the practical application of reaction kinetics, thermodynamics, and transport fundamentals.
  • Possess a sound understanding of the rational design and control of drug substance physical properties at the drug substance-formulation interface, including demonstrated experience in the development and practical application of particle engineering technologies, including crystallization, crystal habit modification/control, wet and dry micronization, spray drying, etc.
  • Possess hands-on experience with modern laboratory instrumentation, experience with the statistical design of experiments, and familiarity with common physical property/process modeling tools (Aspen, Dynochem, gPROMS, etc.) and programming languages (MATLAB, Python, etc).
  • Lead the timely development of novel and creative technical solutions to overcome scale-up and manufacturing obstacles, make substantive conceptual contributions to scientific development strategies, and identify the broad program-level implications of experimental data and models.
  • Possess excellent communication and interpersonal skills and have the ability to interact and collaborate within a large interdisciplinary team comprised of chemical engineers; organic, physical, and analytical chemists; materials and solid-state scientists, and formulation development personnel.
  • Contribute to the drafting of required cGMP, regulatory and technical documentation.


  • BS, MS, or PhD in chemical engineering with 4-10 years of relevant pharmaceutical experience.
  • Proven communication (verbal and written) and interpersonal skills.

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